Dynamic expression of the myocardial sigma-1 receptor after doxorubicin cardiomyopathy using radioiodine-labeled 2-[4-(2-iodophenyl)piperidino]cyclopentanol (OI5 V) imaging
The present study confirmed the expression pattern of σ1R expression after DOX injection. A decrease in σ1R expression detected using <sup>125</sup>I-OI5V may serve as an earlier marker of DOX-induced cardiotoxicity compared with ejection fraction decline.
Authors
- Tomo Hiromasa (ORCID: https://orcid.org/0000-0003-1073-0878)
- Takashi Kozaka
- Junichi Taki (ORCID: https://orcid.org/0000-0003-1753-8192)
- Zhuoqing Chen (ORCID: https://orcid.org/0000-0001-8777-2051)
- Hiroshi Wakabayashi
- Kazuma Ogawa (ORCID: https://orcid.org/0000-0002-1691-7302)
- Seigo Kinuya (ORCID: https://orcid.org/0000-0002-4495-4872)
- Xue Zhang (ORCID: https://orcid.org/0000-0002-5782-2174)
- Hiroshi Mori (ORCID: https://orcid.org/0000-0002-0906-9237)
Institutions
- Kanazawa University (JP)
- Kanazawa Medical University (JP)
- Kanazawa Medical Center (JP)
- Kanazawa University Hospital (JP)
Publication Details
- Journal
- Annals of Nuclear Medicine
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1007/s12149-025-02062-3
- Primary Topic
- Pharmacological Receptor Mechanisms and Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kanazawa University