Serum Lactate Levels and Kinetics Predict Citrate Accumulation in Regional Citrate Anticoagulation for Continuous Renal Replacement Therapy
Regional citrate anticoagulation (RCA) is an established method of anticoagulation for continuous renal replacement therapy (CRRT). Citrate accumulation (CA) is one important complication for RCA-CRRT, especially amongst patients with liver failure or profound hypoxaemia. Accurate diagnosis and prediction of CA remains challenging, where existing means are often limited by their inconvenience, costs and availability. 1,2. Lactate is commonly measured and relatively low-cost laboratory test in the intensive care unit (ICU) setting, and here we reported the follow-up analyses of our previous multi-centre prospective study to determine the clinical utility of serum lactate for monitoring and predicting CA in RCA-CRRT 3.
Authors
- Polly Nga Wing Tsai
- Warren C. W. Chan (ORCID: https://orcid.org/0000-0001-5435-4785)
- Harmony Hau Man To (ORCID: https://orcid.org/0000-0001-9502-4440)
- Irene Yam
- Arthur Ming‐Chit Kwan
- Pauline Yeung Ng (ORCID: https://orcid.org/0000-0001-6671-5963)
- Florence Wong (ORCID: https://orcid.org/0000-0001-9263-8869)
- Chun Wai Ngai (ORCID: https://orcid.org/0000-0002-6852-3946)
- Natalie Yat Yee Leung
- Alfred Sai Kuen Wong (ORCID: https://orcid.org/0000-0002-6785-7418)
- Desmond Y. H. Yap (ORCID: https://orcid.org/0000-0001-8179-8293)
- Tammy Sin Kwan
Institutions
- Imperial College Healthcare NHS Trust (GB)
- Chinese University of Hong Kong (HK)
- Tuen Mun Hospital (CN)
- Queen Mary Hospital (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1016/j.ekir.2025.05.038
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00