Causal Relationship Between Gut Microbiota, Blood Metabolites, and Intervertebral Disc Degeneration: A Two‐Step, Two‐Sample Bidirectional Mendelian Randomization Study
Our study provides evidence supporting a potential causal relationship between certain microbial taxa and intervertebral disc degeneration. This study focuses on the mediation of specific blood metabolites, which suggests that they may represent potential targets for intervention.
Authors
- Lu‐Yang Wang (ORCID: https://orcid.org/0000-0002-5399-944X)
- Yu‐Sheng Xu
- Ximei Zhu (ORCID: https://orcid.org/0000-0001-6875-8801)
- Jinfeng Miao (ORCID: https://orcid.org/0000-0001-6229-3767)
- Donglin Yang (ORCID: https://orcid.org/0000-0002-1768-8644)
- X Li (ORCID: https://orcid.org/0000-0002-9291-6176)
- Yifan Zheng
Institutions
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1002/jsp2.70078
- Citations
- 4
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 5.89