Association Between Body Composition and Cognitive Function in Hispanic/Latine Mid-Life Adults at Risk for Alzheimer’s Disease

significantly reduced 5 of 7 MRSs for biological aging, with the strongest effect for Zhang clock, the MRS with the highest predictive value for mortality (yearly change for MVM versus placebo, -1.03 [95% CI, -1.76 to -0.30] years; P0.006; FDR0.024).MVM also reduced MRSs for 16 of 24 chronic diseases, including cardiometabolic, dementia, and cancer outcomes, only at a nominal level (P< 0.05; FDR >0.05).In prespecified stratified analyses, MVM had stronger effects for all significantly changed MRSs among obese participants.For example, MVM reduced Zhang clock by -2.39 [-4.07 to -0.72] years among those with BMI30 compared with -0.47 [-1.27 to 0.33] years among those with BMI< 30 (FDR0.046 for interaction).Conclusions: The COSMOS trial provides novel evidence that daily MVM supplementation may favorably change metabolomic profiles for older adults, especially among obese individuals, that potentially translate to longer-term health benefits and slowing biological aging.