Bioconverted Red Ginseng Modulates Bile Acid Homeostasis and Gut Microbiome Composition in Aged Mice
significantly effective in reducing tumor weight and volume and enhancing immune responses.Conclusions: A. muciniphila and its derivatives exhibit significant potential as therapeutic agents in cancer management.Their effects are mediated through the modulation of inflammatory pathways, apoptotic processes, microbiota composition, and immune regulation.These findings suggest that A. muciniphila could be a promising next-generation probiotic for cancer therapy, particularly in its non-live forms.Further exploration of A. muciniphila's metabolites and outer membrane proteins could unlock new therapeutic opportunities.
Authors
- Josephine M. Egan (ORCID: https://orcid.org/0000-0002-8945-0053)
- Yoo Kim (ORCID: https://orcid.org/0000-0002-4525-1319)
- Gopal Lamichhane (ORCID: https://orcid.org/0000-0003-1487-7578)
- Jing Liu (ORCID: https://orcid.org/0000-0001-9050-8067)
- Da‐Yeon Lee (ORCID: https://orcid.org/0000-0002-4085-0689)
- Guolong Zhang (ORCID: https://orcid.org/0000-0003-4781-5816)
- Tae Young Kim (ORCID: https://orcid.org/0000-0001-8156-4438)
Institutions
- SMC Corporation (Japan) (JP)
- Oklahoma State University Oklahoma City (US)
- Institute on Aging (US)
- National Institute on Aging (US)
- Institute of Aging (CA)
Publication Details
- Journal
- Current Developments in Nutrition
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.cdnut.2025.106055
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00