Preparation and Efficacy Evaluation of a Tibetan Gentiana Face Mask Suitable for Sensitive Skin

This study aims to investigate the antioxidant activity of Tibetan gentian (Gentiana spp.) extract and its essence when compounded with a facial mask matrix. It also evaluates the efficacy of facial masks containing gentian extract on sensitive facial skin and analyzes the comprehensive performance of the mask. A total of 90 patients with facial sensitive skin, enrolled between October 2022 and December 2024, were randomly assigned to either a control group or an observation group, with 45 patients in each. The control group used standard facial masks, while the observation group used masks containing gentian extract. Both groups underwent a 4-week intervention. The efficacy, lactic acid stinging test indicators, and skin physiological function parameters were compared between the two groups. Results showed that the overall effectiveness rate in the observation group reached 93.26%, significantly higher than 71.20% in the control group (P < 0.05). After the intervention, both groups showed notable improvements compared to baseline in lactic acid stinging test scores and physiological skin indicators. Specifically, the observation group had significantly lower stinging scores and a longer latency before the onset of stinging compared to the control group. Moreover, the skin pH values were lower, while sebum levels and stratum corneum hydration were higher than those in the control group (P < 0.05). No serious adverse events occurred in either group. These findings suggest that facial masks containing gentian extract effectively alleviate symptoms of sensitive facial skin, enhance skin barrier function and tolerance, and are safe for use.