Intermittent Fasting Improves Aging Immunity by Reprogramming Systemic Myeloid Lineage and Tissue Inflammation
Objectives: The rapidly growing aging population has made aging-associated diseases a global challenge, underscoring the critical need for healthy aging interventions. Calorie restriction is known to have health benefits, but long-term compliance is extremely challenging. Intermittent fasting (IF) has recently emerged as a more sustainable alternative to calorie restriction. Chronic low-grade inflammation, also known as “inflammaging,” is a hallmark of aging, underpinning many age-related diseases.
Authors
- Zheng Shen (ORCID: https://orcid.org/0000-0002-0523-0767)
- Yuxiang Sun (ORCID: https://orcid.org/0009-0002-0915-6557)
- Da-Mi Kim (ORCID: https://orcid.org/0000-0003-2445-8289)
- Hye Won Han (ORCID: https://orcid.org/0000-0002-9839-0996)
- Zeyu Liu (ORCID: https://orcid.org/0000-0001-7291-3106)
- Hongying Wang (ORCID: https://orcid.org/0000-0001-8443-3839)
Institutions
- Mitchell Institute (US)
- Texas A&M University (US)
Publication Details
- Journal
- Current Developments in Nutrition
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.cdnut.2025.106019
- Primary Topic
- Dietary Effects on Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute on Aging
- National Institute of Diabetes and Digestive and Kidney Diseases