Assessing the Effects of Different Dietary Fiber Interventions on Kidney Health and Vitamin D Homeostasis in a Preclinical Model of Type 1 Diabetes

Objectives: Type I diabetes (T1D) is an autoimmune disease that if left uncontrolled, increases the risk of renal injury, which can lead to nutritional deficiencies (e.g., vitamin D). We have shown that a dietary intervention with resistant starch (RS, 20%) normalized growth patterns and attenuated vitamin D metabolism, due to the protection of renal health in streptozotocin (STZ)-induced T1D Sprague Dawley (SD) rats. RS elicited the stated effects without improving fasting blood glucose (FBG). This study aimed to evaluate how a 5-day diet intervention with either 5% or 10% RS or WO prior to STZ administration could maintain kidney health, vitamin D balance, and growth patterns.