Human Metabolism of Sorghum bicolor Extracts in Colon Cancer Cells

Objectives: Epidemiological studies support the consumption of whole grains as part of a balanced diet, partly because it may prevent the development of colorectal cancer. Some Sorghum bicolor varietals contain high levels of phytochemicals known to protect plants from oxidative damage. The bioavailability of these phytochemicals and their metabolites ultimately influences their chemopreventive potential. Using colorectal cancer cells grown in transwells as an in vitro model of human digestion, we will identify metabolites generated after treatment with sorghum extracts and investigate potential changes in the expression of genes involved in antioxidant pathways.