The Association Between Sodium-to-Potassium Intake Ratio and Vascular Endothelial Function, and the Role of Insulin Resistance
Objectives: Dietary sodium-to-potassium ratio (Na:K) is a better predictor of cardiovascular disease (CVD) risk than Na+ or K+ intake alone. However, the link between Na:K and vascular endothelial function assessed via flow-mediated dilation (FMD), a subclinical precursor to CVD, is unknown. Further, insulin resistance is associated with higher Na+ intake, lower K+ intake, and greater CVD risk; whether it affects the relation between Na:K and FMD is unknown. The aim of our pilot data analysis was to examine the association between Na+, K+, and Na:K versus FMD, and to explore the role of insulin resistance.
Authors
- Kyle A. Smith (ORCID: https://orcid.org/0000-0002-7016-3038)
- Andrea J. Lobene (ORCID: https://orcid.org/0000-0001-5447-9430)
- Christin Domeier (ORCID: https://orcid.org/0000-0002-3062-5584)
- Thomas G. Bissen (ORCID: https://orcid.org/0009-0003-9660-043X)
- Joseph D. Vondrasek (ORCID: https://orcid.org/0009-0006-8573-5955)
- Joseph C. Watso (ORCID: https://orcid.org/0000-0001-7840-0643)
- Raveen Rani
- William A Mumby
- Hannah E Rajlich
Institutions
- Florida State University (US)
Publication Details
- Journal
- Current Developments in Nutrition
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.cdnut.2025.106199
- Primary Topic
- Sodium Intake and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Heart Association
- Florida State University
- National Institutes of Health