A viral circular RNA in Kaposi’s sarcoma-associated herpesvirus modulates viral and host gene expression during latent and lytic replication
These results show that KSHV can switch to an alternative backsplice site for vIRF4 circRNA production in the absence of a canonical splice site and that circ-vIRF4 contributes to the regulation of both host and viral gene expression through an unknown mechanism.
Authors
- Erik K. Flemington (ORCID: https://orcid.org/0000-0003-0513-5281)
- Shessy Torres
- Rolf Renne (ORCID: https://orcid.org/0000-0001-7391-8806)
- Vaibhav Jain (ORCID: https://orcid.org/0000-0003-2394-3426)
- Daniel Stribling (ORCID: https://orcid.org/0000-0002-0649-9506)
- Scott A. Tibbetts (ORCID: https://orcid.org/0000-0001-8889-1642)
- Lauren A. Gay (ORCID: https://orcid.org/0000-0001-5715-6717)
- Melody Baddoo (ORCID: https://orcid.org/0000-0001-8501-9728)
- Muhammad Naeem
Institutions
- Tulane University (US)
- University of Florida Health (US)
- University of Florida (US)
Publication Details
- Journal
- Exploration of Targeted Anti-tumor Therapy
- Published
- 2025-05-29
- DOI
- https://doi.org/10.37349/etat.2025.1002320
- Citations
- 3
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Institutes of Health