Electronic Nicotine Delivery Systems (ENDS) Use Mediates Drivers of Metabolic Syndrome: Impact on Sugar Intake, BMI and Proteomic Signatures

Objectives: Electronic nicotine delivery systems (ENDS) have rapidly gained popularity since their arrival on the market, safety concerns continue to mount as developments outpace regulatory efforts. Currently, limited evidence exists as to how use of these devices may contribute to metabolic syndrome (MetS). Thus, the objective of this study was to integrate individual nutrition assessments, puffing topography assessments, and salivary proteomics to determine the impact of ENDS use on markers of MetS.