<scp><i>Klebsiella pneumoniae</i></scp> contributes to altered cytotoxicity of thiopurines in vitro: Possible implications of biotransformation and bacterial metabolism
K. pneumoniae decreases the cytotoxicity of thiopurines through internalisation of MP and TG. We revealed potential bacterial drug biotransformation, as well as negative correlations between bacterial abundance and drug metabolites.
Authors
- Manola Comar (ORCID: https://orcid.org/0000-0002-9487-861X)
- Barbara Bellich (ORCID: https://orcid.org/0000-0002-5257-6584)
- Matteo Bramuzzo (ORCID: https://orcid.org/0000-0002-5249-8248)
- Martina Franzin (ORCID: https://orcid.org/0000-0003-1304-6190)
- Gabriele Stocco (ORCID: https://orcid.org/0000-0003-0964-5879)
- Ute Hofmann (ORCID: https://orcid.org/0000-0003-0823-9027)
- Cristina Lagatolla (ORCID: https://orcid.org/0000-0001-5739-6761)
- Elke Schaeffeler (ORCID: https://orcid.org/0009-0005-2997-0355)
- Marianna Lucafò (ORCID: https://orcid.org/0000-0003-1355-3782)
- Mathias Haag (ORCID: https://orcid.org/0000-0001-9017-9021)
- Giuliana Decorti (ORCID: https://orcid.org/0000-0002-9714-6246)
- Sylvia Karin Neef
- Matthias Schwab
- Sofia Sindici Forgiarini
Institutions
- University of Trieste (IT)
- IRCCS Materno Infantile Burlo Garofolo (IT)
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1111/bph.70089
- Citations
- 1
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Robert Bosch Stiftung
- Ministero della Salute