GOS Regulates Bone Mineralization and Ossification Pathways in Intestinal Myeloid Cells: Novel Insights Into the Gut-Bone Axis in Estrogen Deficiency
Objectives: The decline in estrogen with menopause is linked to a proinflammatory state that contributes to osteoporosis. This study aimed to investigate how targeting gut-derived immunomodulators with the prebiotic, galactooligosaccharide (GOS), alters bone and the gut mucosal immune response in ovariectomized (OVX) mice.
Authors
- Ashlee N. Ford Versypt (ORCID: https://orcid.org/0000-0001-9059-5703)
- Jonathan Bard (ORCID: https://orcid.org/0000-0002-4422-9726)
- Mariola Grez-Capdeville
- Brenda J. Smith (ORCID: https://orcid.org/0000-0002-7296-8534)
- Pelumi Adedigba
Institutions
- Indiana University Indianapolis (US)
- Indiana University – Purdue University Indianapolis (US)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Current Developments in Nutrition
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.cdnut.2025.106636
- Primary Topic
- Digestive system and related health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Canadian Institutes of Health Research