Impact of omitting clinical target volume in radiotherapy for locally advanced non-small cell lung cancer: a propensity score matching analysis
Omitting the CTV was associated with a decrease of grade ≥3 radiation-induced toxicities without pejorative impact on PFS or OS in LA-NSCLC patients treated with IMRT. Furthermore, no increase in regional or metastatic recurrence rates were observed. This radiotherapy strategy may be a viable option for selected LA-NSCLC patients, reducing toxicities without compromising outcomes.
Authors
- Petros Christopoulos (ORCID: https://orcid.org/0000-0002-7966-8980)
- Baptiste Abbar (ORCID: https://orcid.org/0000-0002-5907-8131)
- Wen Bao (ORCID: https://orcid.org/0000-0003-0546-0703)
- Ying Zhang (ORCID: https://orcid.org/0000-0002-0019-092X)
- Yaoyao Zhu
- Liang Liu (ORCID: https://orcid.org/0000-0002-7826-3877)
- Qian Cheng (ORCID: https://orcid.org/0000-0002-4750-7859)
- Xiaoshuai Yuan (ORCID: https://orcid.org/0000-0002-4036-0575)
- Shuangyan Yang (ORCID: https://orcid.org/0000-0001-9667-7814)
- Yaping Xu (ORCID: https://orcid.org/0009-0003-6621-0182)
Institutions
- Tongji University (CN)
- Heidelberg University (DE)
- Fudan University (CN)
- University Hospital Heidelberg (DE)
- Zhongshan Hospital (CN)
- Shanghai Pulmonary Hospital (CN)
- German Center for Lung Research (DE)
Publication Details
- Journal
- Translational Lung Cancer Research
- Published
- 2025-05-01
- DOI
- https://doi.org/10.21037/tlcr-2025-409
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00