Salmonella enterica mediated epigenetic promotion of fibrosis is a novel factor in benign prostatic hyperplasia
The findings of this study suggest that S. enterica promotes prostatic fibrosis through ALKBH5-m<sup>6</sup>A-GPX4-mediated ferroptosis. This research offers novel insights for the development of new therapeutic targets and personalized strategies for the prevention and treatment of BPH from the perspectives of microbes and epigenetics.
Authors
- Tiankun Wang (ORCID: https://orcid.org/0000-0001-9378-5422)
- Shaobin Yang (ORCID: https://orcid.org/0000-0003-3057-3603)
- Yang Lü (ORCID: https://orcid.org/0000-0002-8412-809X)
- Haoyue Sun (ORCID: https://orcid.org/0009-0003-3358-7100)
- Minghui Shi (ORCID: https://orcid.org/0000-0001-9676-6972)
- Yusen Zhang (ORCID: https://orcid.org/0000-0003-3842-1153)
- Zhiyuan Jian (ORCID: https://orcid.org/0000-0003-0829-5221)
- Changjiang Qin (ORCID: https://orcid.org/0000-0003-0363-2233)
- Xian‐Tao Zeng (ORCID: https://orcid.org/0000-0003-1262-725X)
- Dao‐Jing Ming (ORCID: https://orcid.org/0000-0002-7918-8119)
- Shuang-Ying Wang
- Cong Zhu
- Fei Li (ORCID: https://orcid.org/0009-0003-8992-2844)
- Wenting Li (ORCID: https://orcid.org/0000-0001-7734-4838)
- Cheng Fang (ORCID: https://orcid.org/0000-0002-1922-0949)
- Tong Deng (ORCID: https://orcid.org/0000-0001-5871-1348)
- Luyao Li (ORCID: https://orcid.org/0000-0003-1397-5045)
- Ting Li (ORCID: https://orcid.org/0009-0008-7260-6331)
- Jia Zhang (ORCID: https://orcid.org/0009-0009-0833-4068)
Institutions
- Guilin Medical University (CN)
- Sichuan University (CN)
- Wuhan University (CN)
- Henan University Huaihe Hospital and Huaihe Clinical Institute (CN)
- West China Hospital of Sichuan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
Publication Details
- Journal
- Military Medical Research
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1186/s40779-025-00614-2
- Citations
- 1
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- Fundamental Research Funds for the Central Universities