Time-Restricted Eating Differentially Affects Bone Health and Visceral Adipose Tissue in Older Women During Caloric Restriction

died.In the unadjusted model, all skewed calorie intake trajectories were associated with higher all-cause mortality compared to the Midday-evening Balance reference group (p< 0.05).After multivariable adjustment, Skewed to Morning (HR1.18;95%CI, 1.01-1.38)and Skewed to Evening (HR1.23;1.03-1.47)patterns remained significantly associated with higher all-cause mortality.These risks were particularly greater among older adults, women, and White individuals.There was a suggestion of Skewed to Morning associating with 42% higher CVD mortality, but it did not reach statistical significance (p0.079).Conclusions: Our analysis suggests that patterns of calorie intake skewed toward morning or evening may be associated with increased all-cause mortality risk compared to more balanced daily intake.These findings highlight the potential importance of timing in dietary recommendations and suggest that further research is needed to confirm these relationships and explore underlying mechanisms.