Examination of the Current Evidence on Suboptimal Vitamin B12 Status and Neuropsychiatric Outcomes
Objectives: Vitamin B12 is an important cofactor for DNA synthesis, myelin formation, and neurotransmitter metabolism. Vitamin B12 status has an established link to neurodegeneration and neuropathy, while associations to other neuropsychiatric conditions remain poorly understood. This study aimed to synthesize the evidence examining associations between suboptimal B12 status and neuropsychiatric outcomes using multiple measures of vitamin B12.
Authors
- Monique Potvin Kent
- Peter Mossey (ORCID: https://orcid.org/0000-0002-9914-6901)
- Natalie Jensen (ORCID: https://orcid.org/0000-0002-4914-0130)
- Chittaranjan S. Yajnik (ORCID: https://orcid.org/0000-0002-2911-2378)
- Lindsey Sikora (ORCID: https://orcid.org/0000-0002-9715-8634)
- Alain Stintzi (ORCID: https://orcid.org/0000-0003-3728-4038)
- Evropi Τheodoratou (ORCID: https://orcid.org/0000-0001-5887-9132)
- Atipatsa Chiwanda Kaminga (ORCID: https://orcid.org/0000-0002-6556-4590)
- Hui Wang (ORCID: https://orcid.org/0000-0003-0181-5845)
- Azita Montazeri
- Derrick Bennett (ORCID: https://orcid.org/0000-0002-9170-8447)
- Julian Little
- Homero Martinez
- Ron Munger
- Michele Rubini (ORCID: https://orcid.org/0000-0003-1448-9516)
- Jennifer C. Lai (ORCID: https://orcid.org/0000-0003-2092-6380)
- Amanda J MacFarlane (ORCID: https://orcid.org/0000-0002-3208-3483)
- Marjanne Senekal (ORCID: https://orcid.org/0000-0002-9427-2319)
- Helene McNulty (ORCID: https://orcid.org/0000-0002-4366-6457)
- Peizhan Chen (ORCID: https://orcid.org/0000-0003-0279-4759)
- Franco Momoli
- Samantha Yoo (ORCID: https://orcid.org/0009-0009-8943-3761)
- Susan J. Duthie (ORCID: https://orcid.org/0000-0002-7990-4437)
- Patrick Mullie
- Rajendra Parajuli
- Ann Yaktine
Institutions
- Utah State University (US)
- Health Canada (CA)
- National Academy of Sciences (US)
- University of Ulster (GB)
- University of Ottawa (CA)
- University of Cape Town (ZA)
- University of Dundee (GB)
- Mzuzu University (MW)
- Shanghai Jiao Tong University (CN)
- University of Ferrara (IT)
- University of California San Diego (US)
- University of Oxford (GB)
- International Prevention Research Institute (FR)
- Singapore Institute for Clinical Sciences (SG)
- Nutrition International (CA)
- Robert Gordon University (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Current Developments in Nutrition
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.cdnut.2025.106946
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00