Abnormalities In Microbiome Contribute to Non-Responsiveness of Ketogenic Diet in Alzheimer’s Disease, and a Novel Synbiotics Formulation Ameliorates Them
Objectives: Ketogenic diet (KD) is beneficial for brain health by ameliorating cognitive impairments, including Alzheimer’s disease (AD); however, while many individuals respond well to KD intervention, many are nonresponsive. In this study, we tested a hypothesis that abnormalities in the microbiome contribute to the non-responsiveness of KD in older adults with mild cognitive impairment (MCI) to ameliorate AD pathology, and a synbiotic yogurt (SY) formulation reverses them.
Authors
- Bryan J. Neth (ORCID: https://orcid.org/0000-0003-2342-0000)
- Hariom Yadav (ORCID: https://orcid.org/0000-0003-4504-1597)
- Suzanne Craft (ORCID: https://orcid.org/0000-0003-0591-8657)
- Adewale Segun James (ORCID: https://orcid.org/0000-0003-3276-8914)
- Diptaraj Chaudhari (ORCID: https://orcid.org/0000-0001-9236-7683)
- Brandi Miller (ORCID: https://orcid.org/0000-0002-6986-999X)
- Sidharth P. Mishra (ORCID: https://orcid.org/0000-0001-7586-846X)
- Shalini Jain (ORCID: https://orcid.org/0000-0001-5200-5928)
- Santosh Kumar Prajapati (ORCID: https://orcid.org/0000-0003-0198-6863)
- Sima Maleki (ORCID: https://orcid.org/0000-0001-8727-9021)
- Dayna Goltz (ORCID: https://orcid.org/0000-0001-8794-0748)
- Divyani Tangudu
- Noorul Ain Adil
- Christabel Omo-erigbe
Institutions
- Wayne State College (US)
- Wayne State University (US)
- University of South Florida (US)
- WinnMed (US)
- Wake Forest University (US)
Publication Details
- Journal
- Current Developments in Nutrition
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.cdnut.2025.106919
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute on Deafness and Other Communication Disorders
- National Center for Complementary and Integrative Health