Evaluating Approaches That Refine Mendelian Randomization Genetic Instruments to Improve Causal Associations Between Dietary Intake and Human Health
Objectives: Mendelian randomization (MR) uses genetic instruments (GI) to identify causality between exposures, like diet, and health outcomes. Almost all MR of dietary intake use a non-curated list of genome-wide significant (GWS) variants as the GI, and therefore, causal estimates are likely biased by variants that act indirectly on diet. We tested whether GWS-GI could detect established relationships between diet and health and whether systematically filtering the GI could better identify the direct effect of diet on health.
Authors
- Liang‐Dar Hwang (ORCID: https://orcid.org/0000-0002-5535-2199)
- Audrey E. Hendricks (ORCID: https://orcid.org/0000-0002-7152-0287)
- Julie E Gervis (ORCID: https://orcid.org/0000-0003-0125-9930)
- Kenneth E. Westerman (ORCID: https://orcid.org/0000-0001-7619-1868)
- Joanne B. Cole (ORCID: https://orcid.org/0000-0001-9520-2788)
- Debashis Ghosh (ORCID: https://orcid.org/0000-0001-6618-1316)
- K. SUTTON
Institutions
- Broad Institute (US)
- The University of Queensland (AU)
- Massachusetts General Hospital (US)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- Current Developments in Nutrition
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.cdnut.2025.107298
- Primary Topic
- Nutrition, Genetics, and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00