Heme-catalyzed reduction of N-oxide and its application to sensing heme and hemoglobin <i>via</i> a chemiluminescent probe
Catalytic reactions are extensively employed to amplify detection signals. Here, we present the overlooked catalytic nature of the heme-mediated reduction of N-oxide and the use of this process to guide the development of a chemiluminescence-based probe (CCP-1). The probe showed, unprecedentedly, similar responses towards free heme and hemoglobin.
Authors
- Xuehui Liu (ORCID: https://orcid.org/0009-0004-5783-2841)
- Chong‐Jing Zhang (ORCID: https://orcid.org/0000-0002-3396-9999)
- Xiang Lv (ORCID: https://orcid.org/0000-0001-6101-7568)
- Pengfei Lei (ORCID: https://orcid.org/0000-0001-9341-4568)
- Chen Chen (ORCID: https://orcid.org/0000-0001-5902-3037)
- Jing Li (ORCID: https://orcid.org/0000-0003-3338-0284)
- Shuang Wang (ORCID: https://orcid.org/0000-0002-5802-7893)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02085a
- Citations
- 2
- Primary Topic
- Hemoglobin structure and function
- Type
- article
- Field-Weighted Citation Impact
- 2.30
Funders
- National Key Research and Development Program of China