Apigenin Suppressed M1 Macrophage Polarization but Did Not Promote M2 Macrophage Polarization in Raw 264.7 Cells

Objectives: M1 and M2 macrophages are responsible for maintaining tissue homeostasis for inflammatory responses. M1 macrophages exhibit proinflammatory responses while M2 macrophages exhibit anti-inflammatory responses. The imbalance between M1 and M2 macrophages is closely related to inflammation-associated disease development. Apigenin (API), a flavonoid present in apiaceous vegetables, is known for its anti-inflammatory properties, however, there is a paucity of data on its potential role in macrophage polarization.