Phase 1 studies of the indenoisoquinolines LMP776 and LMP744 in patients with solid tumors and lymphomas

MTDs and safety profiles are reported for LMP776 and LMP744. Target engagement by an indenoisoquinoline was measured for the first time in human samples.

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Publication Details

Journal
Cancer Chemotherapy and Pharmacology
Published
2025-05-29
DOI
https://doi.org/10.1007/s00280-025-04778-5
Citations
1
Primary Topic
Cancer therapeutics and mechanisms
Type
article
Field-Weighted Citation Impact
0.81

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article

Phase 1 studies of the indenoisoquinolines LMP776 and LMP744 in patients with solid tumors and lymphomas

Shivaani Kummar, Katherine V. Ferry‐Galow, Geraldine O’Sullivan Coyne, Deborah Wilsker et al.
1 citations
Cancer Chemotherapy and Pharmacology
Cancer therapeutics and mechanisms
0.81
article

Phase 1 studies of the indenoisoquinolines LMP776 and LMP744 in patients with solid tumors and lymphomas

Shivaani Kummar, Katherine V. Ferry‐Galow, Geraldine O’Sullivan Coyne, Deborah Wilsker, Jan H. Beumer, Larry Rubinstein, Barry C. Johnson, Murielle Hogu, Joseph M. Covey, James H. Doroshow, Yves Pommier, Joshua J. Deppas, Alice P. Chen, Richard Piekarz, Brian Ko, S. Percy Ivy, Melinda G. Hollingshead, Liza Cosca Villaruz, Julianne L. Holleran, Nancy Young Moore, Ralph E Parchhment
article en
1 citations

Abstract

MTDs and safety profiles are reported for LMP776 and LMP744. Target engagement by an indenoisoquinoline was measured for the first time in human samples.

Cancer Chemotherapy and PharmacologyVol. 95(1)
Leidos (United States) (US), National Institutes of Health (US), Oregon Health & Science University (US), University of Pittsburgh (US), Zimmer Biomet (United States) (US), UPMC Hillman Cancer Center (US), Frederick National Laboratory for Cancer Research (US), National Cancer Institute (US), Center for Cancer Research (US), Science Applications International Corporation (United States) (US)
National Cancer Institute
Good health and well-being
Openalex Percentile: Top 28%
Cancer therapeutics and mechanisms
0.81
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