Comparison of efficacy of exosomes derived from human umbilical cord blood mesenchymal stem cells in treating mouse acute lung injury via different routes
hUCMSC-Exo effectively attenuates LPS-induced ALI in mice. At the tested dose (5 × 10⁸ particles), intravenous delivery exhibited superior therapeutic efficacy over intranasal and nebulized routes.
Authors
- Yi Hui
- Jizhen Zou
- Yiying Huang (ORCID: https://orcid.org/0000-0003-4173-4628)
- Xiaolan Huang (ORCID: https://orcid.org/0000-0002-3330-4858)
- Weilan Na
- Shuang Liu (ORCID: https://orcid.org/0000-0001-5856-0906)
- Jing Chen (ORCID: https://orcid.org/0009-0004-4504-7782)
- Wei Li (ORCID: https://orcid.org/0000-0002-3246-8770)
- Yibin Wang (ORCID: https://orcid.org/0000-0003-0852-0767)
- Lin Bai (ORCID: https://orcid.org/0000-0002-0646-0812)
- Siyuan Huang (ORCID: https://orcid.org/0000-0002-2045-876X)
- Dong Qu
- Haiyan Ge (ORCID: https://orcid.org/0000-0002-6105-1747)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Capital Institute of Pediatrics (CN)
- Institute of Laboratory Animal Science (CN)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-05-29
- DOI
- https://doi.org/10.3389/fped.2025.1560915
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Chinese Academy of Medical Sciences