Early net ultrafiltration thresholds and mortality in critically ill patients with septic acute kidney injury receiving continuous renal replacement therapy

High-intensity NUF during early CRRT was associated with higher mortality in patients with septic AKI mortality, particularly among those with high severity of illness. Moderate NUF had lowest mortality, suggesting that intermediate NUF rates may best balance the competing risks of worsening hemodynamic instability from excess NUF and persistent volume overload from inadequate NUF. However, future trials are needed to better define the optimal approach to NUF in patients with septic AKI.