CBD Dysregulates Synaptic Plasticity Gene Expression Under HIV Infection
Objectives: Synaptic plasticity is the change of synapse strength in response to stimuli. This ability is essential for learning, memory, and overall fitness cognition and can be affected by neurocognitive disorders. HIV-associated neurocognitive disorder (HAND) is characterized by the development of cognitive, behavioral, and motor issues and occurs in approximately 12-25% of HIV-infected individuals. Notably, Cannabidiol, CBD, a non-psychoactive cannabinoid found in the Cannabis plant, is a trendy supplement nowadays, recognized for its anxiolytic, antioxidant, and anti-inflammatory properties and beneficial improvement on cognition.
Authors
- Arti Vashist (ORCID: https://orcid.org/0000-0002-7519-1863)
- Juan P. Liuzzi (ORCID: https://orcid.org/0000-0001-7060-4393)
- Adriana Yndart (ORCID: https://orcid.org/0000-0002-5501-910X)
- Madepalli Krishnappa Lakshmana (ORCID: https://orcid.org/0000-0002-1291-4438)
Institutions
- Florida International University (US)
Publication Details
- Journal
- Current Developments in Nutrition
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.cdnut.2025.106945
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Office of the Director of National Intelligence
- National Institutes of Health
- University of Illinois at Urbana-Champaign
- Intelligence Advanced Research Projects Activity
- National Institute on Aging
- National Institute on Drug Abuse