Cumulative Lipids Exposure Through Young Adulthood and Metabolic Dysfunction-Associated Steatotic Liver Disease in Midlife
Results: The mean age was 45.1 years (95% CI: 23.5 to 66.8); 66% were women, and 65% were Caucasian.OBCO had the highest hs-CRP (median2.2,IQR: 0.8 to 4.8), followed by NWCO (median2.1,IQR: 0.7 to 3.9).The lowest hs-CRP was in NWL (median0.7,IQR: 0.3 to 1.8), with OBL having a median of 1.0 (IQR: 0.4 to 2.5).Controlling for covariates, hs-CRP levels in NWCO were comparable to OBCO ( -.34, SE .29,p > .05),while both NWL and OBL had significantly lower levels than OBCO ( -1.54, SE .10,p < .001,and -1.09, SE .10, p < .001, respectively).BMI-based overweight/obese ( .44,SE .11,p < .001)and central obesity ( 1.10, SE .10,p < .001)independently predicted elevated hs-CRP, with central obesity having a nearly threefold greater effect.Conclusions: Central obesity is linked to elevated hs-CRP levels independent of BMI, suggesting it may pose a greater CVD risk.Assessing central obesity in normal-weight individuals may be crucial for identifying cardiometabolic health issues.
Authors
- Yinan Zheng (ORCID: https://orcid.org/0000-0002-2837-1634)
- J. Jeffrey Carr (ORCID: https://orcid.org/0000-0002-4398-8237)
- Longgang Zhao (ORCID: https://orcid.org/0000-0001-9254-1952)
- Lifang Hou (ORCID: https://orcid.org/0000-0003-4877-0031)
- Hongyan Ning (ORCID: https://orcid.org/0000-0003-1157-6614)
- Donald M. Lloyd‐Jones (ORCID: https://orcid.org/0000-0003-0847-6110)
- John T. Wilkins (ORCID: https://orcid.org/0000-0002-8781-1329)
- Yishu Qu (ORCID: https://orcid.org/0000-0001-5937-3811)
- Norrina B. Allen (ORCID: https://orcid.org/0000-0002-6993-4384)
- James Greg Terry (ORCID: https://orcid.org/0000-0001-6659-3441)
- Michelle T. Long (ORCID: https://orcid.org/0000-0001-6131-3981)
- Kyeezu Kim (ORCID: https://orcid.org/0000-0002-9094-9011)
- Tao Gao (ORCID: https://orcid.org/0000-0002-9462-9349)
- Kai Zhang (ORCID: https://orcid.org/0000-0002-2589-2880)
- Aimin Chen (ORCID: https://orcid.org/0000-0001-9713-6438)
- Xuehong Zhang (ORCID: https://orcid.org/0000-0002-8260-8508)
- Xinyuan Zhang
- Yun Chen (ORCID: https://orcid.org/0009-0001-3783-2199)
Institutions
- Boston University (US)
- Northwestern University (US)
- University of North Texas (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- University of North Texas Health Science Center (US)
- Vanderbilt University (US)
- Yale University (US)
- California University of Pennsylvania (US)
- University School (US)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Current Developments in Nutrition
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.cdnut.2025.107200
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Heart, Lung, and Blood Institute