Dietary Menaquinone-9 Supplementation Does Not Influence Bone Tissue Quality or Bone Mineral Density in Mice
Objectives: Vitamin K has been implicated in skeletal health because vitamin K-dependent proteins are present in bone. While there are multiple forms of vitamin K, most research has focused on phylloquinone, which is found mainly in plant-based foods, and menaquinone-4 (MK4), which is a metabolite of phylloquinone. However, there are additional forms of vitamin K that are bacterially produced that may influence bone health but have not yet been studied extensively. Herein, we evaluated the effects of menaquinone-9 (MK9), a bacterially produced form of vitamin K on bone tissue quality and bone mineral density (BMD) in young mice.
Authors
- Sarah L. Booth (ORCID: https://orcid.org/0000-0002-1525-4025)
- Xueyan Fu (ORCID: https://orcid.org/0000-0001-6766-9129)
- Nicolas Cevallos (ORCID: https://orcid.org/0000-0003-1758-085X)
- M. Kyla Shea (ORCID: https://orcid.org/0000-0002-3202-5582)
- Christopher J. Hernandez (ORCID: https://orcid.org/0000-0002-0712-6533)
- Chongshan Liu (ORCID: https://orcid.org/0009-0008-8302-6543)
- Benjamin N Orbach
- Jennifer Jooha Lee (ORCID: https://orcid.org/0000-0001-6873-6629)
- Minying Liu (ORCID: https://orcid.org/0009-0007-1372-9000)
- Tristan Silfverskiold
Institutions
- Tufts University (US)
- University of California, San Francisco (US)
- Cornell University (US)
- Jean Mayer Human Nutrition Research Center on Aging (US)
Publication Details
- Journal
- Current Developments in Nutrition
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.cdnut.2025.107396
- Primary Topic
- Vitamin K Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00