Effect of S-adenosylmethionine on Lipid Metabolism Through ER Stress Regulation in Hepatocytes

Objectives: Lipid metabolism in the liver plays an important role in the development and progression of liver disease. ER is an organelle that plays an important role in intracellular lipid metabolism, and when ER stress occurs, abnormal lipid metabolism occurs. S-adenosylmethionine (SAMe) is a metabolite of methionine and is known to have various functions including antioxidant properties. In this study, we aimed to determine whether SAMe could affect lipid metabolism by helping to alleviate ER stress in the liver.