Afadin Promotes Vascular Smooth Muscle Cell Contraction by Interacting With Phospholipase C to Enhance Ca <sup>2+</sup> Signaling for Blood Pressure Regulation
Afadin expression in VSMCs promotes cell contraction by interacting with PLCβ to enhance Ca<sup>2+</sup> signaling and has potential as a novel molecular target for blood pressure regulation.
Authors
- Md Rasel Molla (ORCID: https://orcid.org/0000-0003-1059-3201)
- Shunji Suetaka (ORCID: https://orcid.org/0000-0002-4204-3311)
- Munehito Arai (ORCID: https://orcid.org/0000-0002-1223-2242)
- Futoshi Toyoda (ORCID: https://orcid.org/0000-0002-8412-6481)
- Mahbubur Rahman Khan (ORCID: https://orcid.org/0000-0001-9164-4204)
- Hisakazu Ogita (ORCID: https://orcid.org/0000-0001-6750-1668)
- Masahiro Komeno (ORCID: https://orcid.org/0000-0001-7602-8884)
- Masanari Nishida
- Akio Shimizu (ORCID: https://orcid.org/0000-0002-3393-6193)
- Akio Sato (ORCID: https://orcid.org/0009-0009-1979-3921)
- Mst Zenika Nasrin
Institutions
- Tokyo Institute of Technology (JP)
- Shiga University of Medical Science (JP)
- Tokyo University of the Arts (JP)
- The University of Tokyo (JP)
- Mejiro University (JP)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1161/atvbaha.125.322619
- Citations
- 2
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 2.93