Antiproliferative Water-Soluble Mono- and Binuclear Ruthenium Complexes with Pyridone–Imidazole Ligands
In this study, we synthesized and characterized new imidazole ligands containing pyridone groups, as well as mononuclear and binuclear ruthenium complexes, which are a new class of water-soluble metallacycles. We studied the antiproliferative activity of these compounds in vitro using the MTT assay on a panel of human cancer cell lines and on primary rat fibroblasts, where we observed a complete absence of cytotoxicity up to a concentration of 1000 µM. For the binuclear metallocycle compounds, we investigated their solubility in water, resistance to hydrolysis, and ability to induce apoptosis in tumor cells.
Authors
- Alexey A. Nazarov (ORCID: https://orcid.org/0000-0002-5821-1658)
- Ilya A. Shutkov (ORCID: https://orcid.org/0000-0003-0069-8747)
- Nataliya E. Borisova (ORCID: https://orcid.org/0000-0002-0789-5391)
- Konstantin Alexandrovich Lyssenko (ORCID: https://orcid.org/0000-0002-3500-1287)
- Ivan A. Godovikov (ORCID: https://orcid.org/0000-0001-5822-323X)
- D. S. Yakovlev (ORCID: https://orcid.org/0000-0001-8980-6016)
- Nikolai A. Melnichuk
- Е. Р. Милаева (ORCID: https://orcid.org/0000-0002-5489-3866)
- S. A. Ovakimyan
- Dmitrii M. Mazur (ORCID: https://orcid.org/0000-0002-9780-1490)
- Maxim L. Kuznetsov (ORCID: https://orcid.org/0000-0001-5729-6189)
- А. А. Спасов (ORCID: https://orcid.org/0000-0002-7185-4826)
Institutions
- University of Lisbon (PT)
- Volgograd State Medical University (RU)
- Lomonosov Moscow State University (RU)
- A. N. Nesmeyanov Institute of Organoelement Compounds (RU)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2025-05-29
- DOI
- https://doi.org/10.3390/ijms26115214
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Russian Science Foundation