Impact of Y chromosome loss on the risk of Parkinson's disease and progression
G.L.'s work is supported by the Shenzhen Fundamental Research Program (JCYJ20240813151132042), National Natural Science Foundation of China (32270701, 32470708), Young Talent Recruitment Project of Guangdong (2019QN01Y139), the Science and Technology Planning Project of Guangdong Province (2023B1212060018) and Shenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases (ZDSYS20220606100803007). This study is supported by High-performance Computing Public Platform (Shenzhen Campus) of Sun Yat-sen University. C.R.S.'s work is supported by NIH grants NINDS/NIA R01NS115144, the U.S. Department of Defense, and the American Parkinson Disease Association Center for Advanced Parkinson Research. C.R.S.'s research work was funded in part by Aligning Science Across Parkinson's 000301 through the Michael J. Fox Foundation for Parkinson's Research (MJFF). The study was made possible in part by a philanthropic support for Illumina MEGA chip genotyping (to Brigham & Women's Hospital and C.R.S.). CHWG received funding support from an RCUK/UKRI Research Innovation Fellowship awarded by the Medical Research Council (MR/R007446/1; MR/W029235/1) and from the NIHR Cambridge Biomedical Research Centre (NIHR203312). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. For the purpose of open access, the author has applied a CC BY public copyright licence to all Author Accepted Manuscripts arising from this submission.
Authors
- Jean‐Christophe Corvol (ORCID: https://orcid.org/0000-0001-7325-0199)
- Caroline H. Williams‐Gray (ORCID: https://orcid.org/0000-0002-2648-9743)
- Jodi Maple‐Grødem (ORCID: https://orcid.org/0000-0001-7142-0078)
- Clemens R. Scherzer (ORCID: https://orcid.org/0000-0002-0567-9193)
- Alexis Brice (ORCID: https://orcid.org/0000-0002-0941-3990)
- Ganqiang Liu
- Ole‐Bjørn Tysnes (ORCID: https://orcid.org/0000-0002-7230-6426)
- Sulev Kõks (ORCID: https://orcid.org/0000-0001-6087-6643)
- Jacobus J. van Hilten (ORCID: https://orcid.org/0000-0002-7030-0362)
- Michael A. Schwarzschild (ORCID: https://orcid.org/0000-0001-6019-8280)
- Cha Lin
- Baijayanta Maiti (ORCID: https://orcid.org/0000-0002-2583-4947)
- Alexis Elbaz (ORCID: https://orcid.org/0000-0001-9724-5490)
- Suzanne Lesage (ORCID: https://orcid.org/0000-0003-4158-2601)
- Meghan C. Campbell (ORCID: https://orcid.org/0000-0003-3030-9669)
- Guido Alves (ORCID: https://orcid.org/0000-0003-0630-2870)
- Pille Taba
- Roger A. Barker (ORCID: https://orcid.org/0000-0001-8843-7730)
- Xinyi Chen (ORCID: https://orcid.org/0009-0006-0121-5355)
- Liao Yu
- Joel S. Perlmutter
- Junhao Wang (ORCID: https://orcid.org/0009-0006-5632-6407)
- Wenxuan Du (ORCID: https://orcid.org/0000-0002-0185-8071)
Institutions
- Harvard University (US)
- Inserm (FR)
- Sun Yat-sen University (CN)
- Murdoch University (AU)
- Shenzhen University (CN)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Washington University in St. Louis (US)
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- University of Cambridge (GB)
- Université Paris-Saclay (FR)
- Leiden University Medical Center (NL)
- Stavanger University Hospital (NO)
- Haukeland University Hospital (NO)
- Tartu University Hospital (EE)
- Yale University (US)
- Sorbonne Université (FR)
- Massachusetts General Hospital (US)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- Perron Institute for Neurological and Translational Science (AU)
- Institut du Cerveau (FR)
Publication Details
- Journal
- EBioMedicine
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1016/j.ebiom.2025.105769
- Citations
- 2
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- U.S. Department of Defense
- Michael J. Fox Foundation for Parkinson's Research
- Massachusetts General Hospital
- American Parkinson Disease Association
- UK Research and Innovation
- National Institute for Health and Care Research
- Department of Health and Social Care
- Research Councils UK
- National Natural Science Foundation of China
- Sun Yat-sen University
- Shenzhen Fundamental Research Program
- National Institutes of Health
- Medical Research Council
- Science and Technology Planning Project of Guangdong Province
- NIHR Cambridge Biomedical Research Centre
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke