Multiomic Landscape of Extracellular Vesicles in Human Carotid Atherosclerotic Plaque Reveals Endothelial Communication Networks
Our findings indicate that EVs may drive dynamic changes in plaques through EV-vascular cell communication and effector functions that typify vulnerability to rupture, precipitating symptomatic disease. The discovery of endothelial-directed angiogenic processes mediated by EVs creates new therapeutic avenues for atherosclerosis.
Authors
- Natalie J. Galant
- Michael A. Seidman (ORCID: https://orcid.org/0000-0002-9594-827X)
- Sasha A. Singh (ORCID: https://orcid.org/0000-0003-0929-3164)
- Sneha Raju (ORCID: https://orcid.org/0000-0001-9149-5907)
- Steven R. Botts (ORCID: https://orcid.org/0000-0002-2420-4679)
- Melody Chemaly (ORCID: https://orcid.org/0000-0001-6211-7595)
- Sarvatit Patel (ORCID: https://orcid.org/0000-0002-3101-8380)
- Vallijah Subasri (ORCID: https://orcid.org/0000-0002-6584-877X)
- Kathryn L. Howe (ORCID: https://orcid.org/0000-0002-6519-2280)
- Dakota Gustafson (ORCID: https://orcid.org/0000-0001-8374-6331)
- Mark C. Blaser (ORCID: https://orcid.org/0000-0002-3923-9786)
- Ljubica Matic (ORCID: https://orcid.org/0000-0002-7294-9667)
- Christian Cao (ORCID: https://orcid.org/0000-0002-0395-0381)
- Elena Aïkawa (ORCID: https://orcid.org/0000-0001-7835-2135)
- Kamalben Prajapati
- Ulf Hedin (ORCID: https://orcid.org/0000-0001-9212-3945)
- Jason E. Fish (ORCID: https://orcid.org/0000-0003-0640-7277)
- Rachel M. Cahalane (ORCID: https://orcid.org/0000-0003-4017-0592)
- Lindsey K. Fiddes
- Mandy E. Turner (ORCID: https://orcid.org/0000-0001-6431-5077)
- Majed Abdul-Samad (ORCID: https://orcid.org/0009-0006-6007-3190)
- Neil Punwasi
- Ruilin Wu (ORCID: https://orcid.org/0009-0009-9229-3819)
Institutions
- Brigham and Women's Hospital (US)
- University Health Network (CA)
- Karolinska University Hospital (SE)
- University of Toronto (CA)
- Ollscoil na Gaillimhe – University of Galway (IE)
- Toronto General Hospital (CA)
- Princess Margaret Cancer Centre (CA)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1161/atvbaha.124.322324
- Citations
- 4
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 3.22