Research Progress on the Toxic Effect and Pathogenic Mechanism of Atmospheric Particulate Matter on Respiratory System

大气颗粒物是空气污染的重要组成部分，可导致各类呼吸系统疾病，研究表明颗粒物能够通过减弱呼吸系统防御功能、引起氧化应激和炎症、改变表观遗传等方式致病。本文就大气颗粒物对呼吸系统的毒性作用及致病机制方面的研究进展作一综述。Atmospheric particulate matter is an important part of air pollution and can lead to various respiratory diseases. Studies have shown that particulate matter can cause disease by weakening the defense function of respiratory system, causing oxidative stress and inflammation, changing epigenetics and so on. This paper reviews the research progress of toxic effect and pathogenic mechanism of atmospheric particulate matter on respiratory system.