CLSI Validation of Exchangeable Copper Determination in Serum by ICP-MS: A Focus on Alzheimer’s Disease and Wilson Disease
The validated ExcCu assay overcomes the limitations of the traditional non-Cp Cu calculation, offering a reliable biomarker for copper-related AD subtypes. Its high specificity supports its use in patient stratification, potentially contributing to personalized approaches in AD diagnosis and therapy.
Authors
- Amit Pal (ORCID: https://orcid.org/0000-0001-9916-3309)
- Massimo Marianetti (ORCID: https://orcid.org/0000-0002-1402-3831)
- Rosanna Squitti (ORCID: https://orcid.org/0000-0002-5624-1140)
- Mauro Rongioletti
- Irena Ivanova (ORCID: https://orcid.org/0000-0003-2369-0182)
Institutions
- Università degli Studi eCampus (IT)
- University Hospital St. Ivan Rilski (BG)
- Fatebenefratelli Hospital (IT)
- All India Institute of Medical Sciences (IN)
Publication Details
- Journal
- Biomolecules
- Published
- 2025-05-29
- DOI
- https://doi.org/10.3390/biom15060788
- Citations
- 5
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 5.60