Gene Expression Analysis of (Paired) Primary and Relapsed Wilms Tumor Samples to Unravel the Underlying Factors Driving Tumor Recurrence
The CSC pool could play a role in relapse through immune regulation and tumor propagation. Differentiation of CSCs into mesenchymal cells might attenuate the risk of relapse. Our prediction model might aid in selecting patients with an increased risk of relapse at primary diagnosis when externally validated.
Authors
- Alida F. W. van der Steeg (ORCID: https://orcid.org/0000-0003-0168-7513)
- Annelies M. C. Mavinkurve‐Groothuis (ORCID: https://orcid.org/0000-0002-6984-3626)
- Marry M. van den Heuvel‐Eibrink (ORCID: https://orcid.org/0000-0002-7760-879X)
- Jarno Drost (ORCID: https://orcid.org/0000-0002-2941-6179)
- Annemieke Simone Littooij (ORCID: https://orcid.org/0000-0002-1839-0882)
- Alissa Groenendijk (ORCID: https://orcid.org/0000-0001-6466-7785)
- Ronald R. de Krijger (ORCID: https://orcid.org/0000-0001-6871-1296)
- Martine van Grotel (ORCID: https://orcid.org/0000-0002-8849-8573)
- Lennart A. Kester (ORCID: https://orcid.org/0000-0002-8259-9971)
- Geert O. Janssens (ORCID: https://orcid.org/0000-0002-0331-713X)
Institutions
- University Medical Center Utrecht (NL)
- Oncode Institute (NL)
- Princess Máxima Center (NL)
- Wilhelmina Children's Hospital (NL)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1002/cam4.70969
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 0.00