Elevated Plasma Neurofilament Light Chain Levels in Children with Infantile‐Onset Ascending Hereditary Spastic Paralysis
Plasma NfL levels are elevated in IAHSP, suggesting axonal degeneration. These pilot findings highlight NfL as a potential marker for disease activity, warranting further investigation in larger cohorts and longitudinal studies.
Authors
- Kaitlyn Warren (ORCID: https://orcid.org/0000-0002-1273-3354)
- Kathryn Yang (ORCID: https://orcid.org/0009-0004-6892-5189)
- Hyo‐Min Kim (ORCID: https://orcid.org/0000-0002-2667-3719)
- Amy Tam (ORCID: https://orcid.org/0000-0003-2072-3436)
- Darius Ebrahimi‐Fakhari (ORCID: https://orcid.org/0000-0002-0026-4714)
- Julian E. Alecu (ORCID: https://orcid.org/0000-0002-1420-9775)
- Rebekah Mannix (ORCID: https://orcid.org/0000-0003-3608-2792)
- Filippo Maria Santorelli (ORCID: https://orcid.org/0000-0002-1359-9062)
- Stefania Della Vecchia (ORCID: https://orcid.org/0000-0002-2066-2162)
- Vicente Quiroz (ORCID: https://orcid.org/0009-0005-9212-0943)
- Umar Zubair (ORCID: https://orcid.org/0009-0005-7081-4004)
- Nicole Battaglia (ORCID: https://orcid.org/0009-0008-9751-4580)
- Joshua Rong (ORCID: https://orcid.org/0009-0001-5277-5794)
Institutions
- Boston Children's Hospital (US)
- Harvard University (US)
- Fondazione Stella Maris (IT)
Publication Details
- Journal
- Movement Disorders Clinical Practice
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1002/mdc3.70157
- Citations
- 2
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 2.78