Pd‐Catalyzed Intramolecular Vinyl C–H Acylation with Carboxyl Group: A Facile Access to 1‐Indenones

Comprehensive Summary 1‐Indenones commonly occur in many bioactive and material molecules, thus their highly efficient synthesis attracts much attention from the synthetic community. In this manuscript, we reported an efficient method for their preparation. This reaction used the ortho ‐vinyl carboxylic acids as the starting material and took place through the intramolecular vinyl C–H acylation with carboxyl group. By the strategy, a wide range of 1‐indenones, including both 3‐substituted and 2,3‐disubstituted ones, were precisely synthesized in high yields. Moreover, this reaction featured a high functional group tolerance. In addition, this reaction could be scaled up without any decrease in the reaction efficiency. We anticipate this new reaction will find wide applications in organic synthesis.