Enhancing systemic lupus erythematosus treatment outcomes with an early initiation of belimumab: insights from a multicenter retrospective study within the first five years
These results highlight the importance of early BEL initiation in SLE, demonstrating that patients with shorter disease durations achieve more substantial improvements in disease activity with early BEL treatment. Our findings also reveal the potential benefits of early BEL intervention and suggest that incorporating the disease duration into treatment decisions may optimize patient outcomes.
Authors
- Masako Furuyama
- Taiichiro Miyashita
- Yoshiro Horai (ORCID: https://orcid.org/0000-0002-2366-3566)
- Shuntaro Sato (ORCID: https://orcid.org/0000-0002-6055-3649)
- Masataka Umeda (ORCID: https://orcid.org/0000-0002-6647-7130)
- Kunihiro Ichinose (ORCID: https://orcid.org/0000-0001-8794-7106)
- Takahisa Suzuki (ORCID: https://orcid.org/0000-0001-5680-4823)
- Keita Fujikawa
- Toshimasa Shimizu (ORCID: https://orcid.org/0000-0003-0036-2039)
- Toshiyuki Aramaki (ORCID: https://orcid.org/0000-0003-4112-7000)
- Naoki Matsuoka
- Kanako Kojima (ORCID: https://orcid.org/0009-0004-3284-3456)
- Atsushi Kawakami (ORCID: https://orcid.org/0000-0002-1512-8782)
- Akitomo Okada
- Yoshikazu Nakashima
Institutions
- Japanese Red Cross Society, Japan (JP)
- Sasebo City General Hospital (JP)
- Nagasaki Ajisai Hospital (JP)
- Nagasaki Medical Center (JP)
- Japan Community Healthcare Organization (JP)
- Center for Rheumatology (US)
- Nagasaki University Hospital (JP)
- Nagasaki University (JP)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1186/s13075-025-03581-0
- Citations
- 2
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 3.34
Funders
- Japan Society for the Promotion of Science