PIASy deficiency mitigates thoracic aortic aneurysm formation via the TGF-β/Smad2/3 pathway
The loss of PIASy provides protection against TAA by regulating VSMC differentiation via the TGF-β/Smad pathway. Targeting PIASy may represent a promising therapeutic strategy for the prevention and treatment of TAA.
Authors
- Hui Zheng
- Yucheng Hou (ORCID: https://orcid.org/0000-0002-8326-2043)
- Yinglong Ding
- Kejie Shao
- Dafu Shen
- Jingze Zhu
Institutions
- Shanghai Jiao Tong University (CN)
- Soochow University (CN)
- Shanghai First People's Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Journal of Thoracic Disease
- Published
- 2025-05-01
- DOI
- https://doi.org/10.21037/jtd-2025-984
- Citations
- 2
- Primary Topic
- Connective tissue disorders research
- Type
- article
- Field-Weighted Citation Impact
- 3.63