Optimized Production of Virus-like Particles in a High-CHO-Cell-Density Transient Gene Expression System for Foot-and-Mouth Disease Vaccine Development
Our results demonstrate the feasibility of using CHO cell-based TGE for producing immunogenic FMDV VLPs. This platform shows promise for scalable, cost-effective, and biosafe development of recombinant FMD vaccines.
Authors
- Cintia Sánchez
- Andrés Wigdorovitz (ORCID: https://orcid.org/0000-0001-6445-9505)
- Romina Scian
- Alejandra Ferella (ORCID: https://orcid.org/0000-0002-3848-4595)
- Sabrina Beatriz Cardillo (ORCID: https://orcid.org/0000-0002-7111-2689)
- Yves Durocher (ORCID: https://orcid.org/0000-0002-2268-4111)
- Ana Clara Mignaqui
- Jorge Filippi
- Matthew Stuible (ORCID: https://orcid.org/0009-0002-4403-0677)
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- National Research Council Canada (CA)
Publication Details
- Journal
- Vaccines
- Published
- 2025-05-29
- DOI
- https://doi.org/10.3390/vaccines13060581
- Citations
- 1
- Primary Topic
- Animal Disease Management and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.90