Deciphering the Transcription Factor Landscape in Prostate Cancer Progression: A Novel Approach to Understand NE Transdifferentiation (Adv. Sci. 20/2025)
NeuroeNdocriNe TraNsdiFFereNTiaTioNInspired by the silk-to-wing narrative, this frontispiece illustrates prostate cancer lineage transition.Adenocarcinoma appears as a caterpillar, entering a dormant chrysalis for reprogramming before emerging as a neuroendocrine prostate cancer butterfly.A drifting DNA helix, interwoven with transcription factor stones in a fluid backdrop, symbolizes the dynamic regulatory shifts driving transdifferentiation.More details can be found in article number 2404938 by Yuzhuo Wang and co-workers.
Authors
- Mingchen Shi
- Arul M. Chinnaiyan (ORCID: https://orcid.org/0000-0001-9282-3415)
- Francesco Crea (ORCID: https://orcid.org/0000-0002-4903-2973)
- Abhijit Parolia (ORCID: https://orcid.org/0000-0003-0238-221X)
- Rebecca Wu (ORCID: https://orcid.org/0000-0002-8065-4498)
- Yen‐Yi Lin (ORCID: https://orcid.org/0000-0002-4379-1231)
- Xinyao Pang
- Colin C. Collins (ORCID: https://orcid.org/0000-0001-6148-6110)
- Connie Kang
- Martin Gleave (ORCID: https://orcid.org/0000-0003-4235-0167)
- Junru Chen (ORCID: https://orcid.org/0000-0003-4553-6979)
- Xiaohui Zhu (ORCID: https://orcid.org/0000-0001-9146-8909)
- Christopher J. Ong (ORCID: https://orcid.org/0000-0002-0175-8724)
- Hui Xue (ORCID: https://orcid.org/0000-0002-7970-8647)
- Dong Lin (ORCID: https://orcid.org/0000-0002-0303-2599)
- Zheng Chen (ORCID: https://orcid.org/0000-0002-6582-847X)
- Yu Wang (ORCID: https://orcid.org/0000-0003-1753-0289)
- Yuzhuo Z. Wang (ORCID: https://orcid.org/0000-0002-9749-8591)
- Yuchao Ni
- Xin Dong (ORCID: https://orcid.org/0000-0003-3487-4892)
- Jonathan Cao
Publication Details
- Journal
- Advanced Science
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/advs.202570153
- Citations
- 1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52