Seven Anti-Inflammatory Diarylheptanoid-Indole Alkaloid Hybrids from the Fruits of <i>Amomum maximum</i>
Seven novel diarylheptanoid-indole hybrid alkaloids (<b>1</b>-<b>7</b>) were isolated and characterized from the fruits of <i>Amomum maximum</i>. Their structures were elucidated through a combination of spectroscopic analyses and quantum chemical calculations, with a plausible biosynthetic pathway proposed. Biological evaluation demonstrated that compounds <b>1</b>-<b>4</b> and <b>7</b> exhibited comparable or superior anti-inflammatory activity to dexamethasone in suppressing the release of NO, IL-6, and TNF-α in LPS/IFN-γ-activated RAW264.7 murine macrophages.
Authors
- Li-Bo Wang (ORCID: https://orcid.org/0009-0005-9918-996X)
- Jin‐Na Zhao
- Jinhui Wang (ORCID: https://orcid.org/0000-0003-3658-360X)
- Lu Chen
- Shufei Yu
- Zhihang Wu (ORCID: https://orcid.org/0009-0008-7854-4100)
- Bo Li (ORCID: https://orcid.org/0000-0002-2526-1675)
- Yanjun Ding (ORCID: https://orcid.org/0000-0001-9747-8112)
Institutions
- Harbin Medical University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1021/acs.orglett.5c01654
- Citations
- 1
- Primary Topic
- Ginger and Zingiberaceae research
- Type
- article
- Field-Weighted Citation Impact
- 1.56
Funders
- Harbin Medical University