Retrospective comprehensive analysis of regional lymph node recurrence in breast cancer patients (REASON study)
Our study confirms that patients treated with SLN do not show a higher risk of LRNR compared to ALND. LRNR is often diagnosed incidentally. Younger age, residual disease post-NAC, no regional radiation, stage II, and initial LN involvement were more represented, as well as patients with endocrine sensitive disease classified as low-risk luminal A by MB. Ongoing trials, including SOUND, INSEMA, and BOOG 2013-08, are further exploring axillary surgery de-escalation.
Authors
- Lana E. Kandalaft (ORCID: https://orcid.org/0000-0002-1575-6674)
- Athina Stravodimou (ORCID: https://orcid.org/0000-0002-9608-985X)
- Jean‐Yves Meuwly (ORCID: https://orcid.org/0000-0003-4522-6444)
- Jean‐Philippe Brouland (ORCID: https://orcid.org/0000-0003-3475-0101)
- John Olivier Prior (ORCID: https://orcid.org/0000-0003-1429-1374)
- Jean‐Paul Rivals (ORCID: https://orcid.org/0000-0002-5525-1435)
- Audrey Goupil
- Marzio Bergomi
- Khalil Zaman
- Aikaterini Liapi (ORCID: https://orcid.org/0000-0002-5354-0989)
- Marie Nicod Lalonde (ORCID: https://orcid.org/0000-0002-4886-0611)
- Elsa Curtit (ORCID: https://orcid.org/0000-0003-4814-8680)
- Veronica Aedo-Lopez (ORCID: https://orcid.org/0000-0003-0629-4508)
- Assia Ifticene‐Treboux (ORCID: https://orcid.org/0000-0003-2694-4491)
- Loïc Lelièvre (ORCID: https://orcid.org/0000-0001-7970-3099)
- Laetitia Rossier (ORCID: https://orcid.org/0000-0003-4905-2920)
- Wendy Jeanneret‐Sozzi (ORCID: https://orcid.org/0000-0002-9661-2428)
Institutions
- Centre Hospitalier Universitaire Vaudois (CH)
- Centre Hospitalier Universitaire de Besançon (FR)
- Methodology and Quality of Life Unit in Oncology (FR)
- University of Lausanne (CH)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1007/s00432-025-06235-5
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Université de Lausanne