Short Anagen Hair Syndrome and Its Association With <scp>WNT10A</scp> Gene Variants: A Report of Three Pediatric Cases

Short anagen hair syndrome (SAHS) is a rare hair disorder characterized by a shortened anagen phase, limiting hair growth to a few centimeters. SAHS is a benign condition often improving after puberty, with diagnosis supported by clinical, trichological, and genetic findings. We report three pediatric cases of persistently short hair, all with negative hair pull tests and trichogram findings revealing club-shaped roots, tapering, and hair shaft diameter variability. Genetic testing identified the c.682 T>A;p.(Phe228Ile) variant in heterozygosity in the WNT10A gene in two patients, a variant reported as a risk factor for the condition.

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Publication Details

Journal
Pediatric Dermatology
Published
2025-05-29
DOI
https://doi.org/10.1111/pde.15976
Primary Topic
Hair Growth and Disorders
Type
article
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article

Short Anagen Hair Syndrome and Its Association With WNT10A Gene Variants: A Report of Three Pediatric Cases

Á. Hernández‐Martín, Lucero Noguera‐Morel, Nelly Marlene Román Mendoza, Nelmar Valentina Ortiz‐Cabrera et al.
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Hair Growth and Disorders
article

Short Anagen Hair Syndrome and Its Association With WNT10A Gene Variants: A Report of Three Pediatric Cases

Á. Hernández‐Martín, Lucero Noguera‐Morel, Nelly Marlene Román Mendoza, Nelmar Valentina Ortiz‐Cabrera, Barbara Fernández Garoz, Sergio García‐González, Magdalini Louka
article en

Abstract

Short anagen hair syndrome (SAHS) is a rare hair disorder characterized by a shortened anagen phase, limiting hair growth to a few centimeters. SAHS is a benign condition often improving after puberty, with diagnosis supported by clinical, trichological, and genetic findings. We report three pediatric cases of persistently short hair, all with negative hair pull tests and trichogram findings revealing club-shaped roots, tapering, and hair shaft diameter variability. Genetic testing identified the c.682 T>A;p.(Phe228Ile) variant in heterozygosity in the WNT10A gene in two patients, a variant reported as a risk factor for the condition.

Pediatric DermatologyVol. 42(6)
Hospital Infantil Universitario Niño Jesús (ES)
Good health and well-being
Openalex Percentile: Top 83%
Hair Growth and Disorders
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