A comparison of frequentist and Bayesian approaches to the Personalised Randomised Controlled Trial (PRACTical)—design and analysis considerations
Utilising uncertainty intervals on the treatment coefficient estimates are highly conservative, limiting applicability to large pragmatic trials. Bayesian analysis performed similarly to the frequentist approach in terms of predicting the true best treatment.
Authors
- Joo Wei Chua (ORCID: https://orcid.org/0000-0001-9273-8130)
- Yin Mo (ORCID: https://orcid.org/0000-0002-0216-9550)
- Holly Jackson (ORCID: https://orcid.org/0000-0003-0646-6437)
- Yiyun Shou (ORCID: https://orcid.org/0000-0002-7386-0031)
- Marlieke E.A. de Kraker (ORCID: https://orcid.org/0000-0003-0903-8614)
- Xinru Wang (ORCID: https://orcid.org/0009-0001-5993-708X)
- R. Pérez
- Nur Amira Binte Mohamed Azad
Institutions
- Australian National University (AU)
- National University of Singapore (SG)
- World Health Organization (CH)
- Duke-NUS Medical School (SG)
- National University Hospital (SG)
- National University Health System (SG)
Publication Details
- Journal
- BMC Medical Research Methodology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1186/s12874-025-02537-x
- Citations
- 1
- Primary Topic
- Statistical Methods in Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.63
Funders
- Wellcome Trust
- European Commission
- Ministry of Education - Singapore
- Medical Research Council
- National Medical Research Council