ACE2 shedding exacerbates sepsis-induced gut leak via loss of microbial metabolite 5-methoxytryptophan
ACE2 plays a protective role in maintaining intestinal barrier function during sepsis, potentially through modulation of the gut microbiota and the production of key metabolite 5-MTP. Our study enriched the mechanisms by which ACE2 regulates gut homeostasis and shed light on further applications. Video Abstract.
Authors
- Qihan Xu
- Wanfu Cui (ORCID: https://orcid.org/0009-0000-5929-0696)
- Jiacheng Gong
- Yuanyuan Ma (ORCID: https://orcid.org/0000-0001-6157-0793)
- Anni Lou
- Ying Meng (ORCID: https://orcid.org/0000-0001-8865-652X)
- Weihua Song (ORCID: https://orcid.org/0000-0001-7633-7919)
- Yuhan Li (ORCID: https://orcid.org/0000-0002-0133-7065)
- Zhiwei Chen (ORCID: https://orcid.org/0000-0002-4511-2888)
- Xi Liu (ORCID: https://orcid.org/0000-0002-6318-7509)
- Xu Li (ORCID: https://orcid.org/0000-0002-6994-227X)
- Haoyang Lu (ORCID: https://orcid.org/0000-0002-7525-5505)
- Peng Qu
- Quan Li (ORCID: https://orcid.org/0000-0001-8563-1802)
Institutions
- Nanfang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1186/s40168-025-02128-4
- Citations
- 5
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.77
Funders
- National Natural Science Foundation of China
- Nanfang Hospital