Impact of Statin Intolerance on Functional Capacity and Quality of Life in Patients with Cardiovascular Comorbidities

Background: Long-term statin therapy is essential in managing cardiovascular risk but may lead to muscle-related adverse effects, contributing to functional limitations and diminished quality of life. This study explores the functional impact of statin intolerance among patients with cardiovascular comorbidities. Objective: To assess the effect of statin intolerance-associated muscle symptoms on physical functioning and perceived quality of life in patients on long-term statin therapy. Methods: An observational cross-sectional study was conducted among 110 patients aged 30 to 80 years on statins for at least one year. Data on muscle-related symptoms, occupation type, functional limitations, and biochemical markers were collected. Functional limitation was inferred from the site and severity of muscle pain, physical performance status, and change in activity patterns. Results: Among 110 patients, 56 (51%) reported muscle-related complaints. Of these, 55 (98.2%) experienced pain in the hip flexors, thighs, or calves, and 43 (76.7%) had pain in the shoulders or proximal upper limbs. Pain was more common during movement (61.8%) than palpation (20%). Patients reporting pain had significantly greater physical limitation, especially in moderate and heavy occupation categories. Pain symptoms were exacerbated by exertion in 48% of cases. Elevated CK levels were found in 24.5% of symptomatic patients. Approximately 68% of symptomatic patients reported reduced mobility, 43% had difficulty performing household chores, and 21% had partially withdrawn from previously routine activities. Nearly 18% of affected individuals reported symptoms of low mood, anxiety, or social withdrawal secondary to physical limitation. Conclusion: Statin intolerance, particularly muscle-related symptoms, significantly impairs functional capacity and may adversely affect quality of life in patients with cardiovascular comorbidities. Clinical recognition and individualized statin management may help preserve function and enhance patient wellbeing.