Synergistic Cobaloxime Catalysis for Photo-Dehydrogenative Transformations

Cobaloxime catalysis has emerged as a powerful tool for promoting dehydrogenation reactions and enabling small-molecule functionalization under environmentally benign conditions. These transformations are essential for constructing sp2-hybridized C–C bonds, crucial for synthesizing high-value alkenes, arenes, and heterocycles with applications in pharmaceuticals, agrochemicals and advanced materials. The integration of cobaloxime with photoredox catalysis further enhances reaction efficiency, offering improved selectivity and yields under milder conditions. This review highlights recent advancements in the application of cobaloxime within metallaphotoredox catalysis, with a focus on its effectiveness in dehydrogenation processes that drive the formation of sp2-hybridized C–C bonds via hydrogen atom transfer (HAT) and related pathways.