Granular Cell Ameloblastomatous Transformation From the Remnants of a Dentigerous Cyst: A Unique Case Report

Granular cell ameloblastoma is a unique, infrequent histologic variant of unicystic/multicystic ameloblastoma showing distinct histologic and immunohistochemical features. The prognosis and treatment are similar to other common subtypes of solid or multicystic ameloblastoma. Granular cell ameloblastoma should be distinguished from other lesions with granular cells mainly due to its high risk of recurrence. Although it is rare, it has greater recurrence potential and chances of malignant potential. A better knowledge of the molecular pathogenesis of ameloblastoma and its various subtypes may provide diagnostic and therapeutic benefits. We are reporting a case of granular cell ameloblastoma arising from the wall of a dentigerous cyst. The lining of the dentigerous cyst shows a potential for neoplastic transformation to ameloblastoma, squamous cell carcinoma, and mucoepidermoid carcinoma.